Sodium zirconium cyclosilicate 

Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K⁺ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD)^[1][2].

Sodium zirconium cyclosilicate (ZS-9) 是一种无机阳离子交换晶体化合物，具有高选择性截留单价阳离子的能力，特别是过量的 K⁺ 和铵离子。Sodium zirconium cyclosilicate 对二价离子 Ca²⁺ 和 Mg²⁺ 的交换容量均低于 0.05 mEq/g，对 K⁺ 选择性超过 Ca²⁺ 或 Mg²⁺ >25 倍^[1]。
溶解注意事项：Sodium zirconium cyclosilicate 通常配置悬浮液作为储备液，分装储存在 -80℃。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

371.50

H₆O₉Si₃.2Na.Zr

17141-74-1

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686.  [Content Brief]

  [2]. Ash SR, et, al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88(2):404-11.  [Content Brief]